HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-(2-Fluoroethyl)piperazine dihydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 1,4-Dioxane | HCID 31275 | — |
| Reactant | tert-Butyl 4-(2-fluoroethyl)piperazine-1-carboxylate | HCID 21082715 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-(2-Fluoroethyl)piperazine dihydrochloride | HCID 66545688 | — |
Reaction Steps
Add 4 N HCl in 1,4-dioxane (21.52 mL, 86.1 mmol) to a stirred solution of 4-(2-fluoro-ethyl)-piperazine-1-carboxylic acid tert-butyl ester (2.00 g, 8.61 mmol) in dry dichloromethane (60 mL) at room temperature under nitrogen. Stir overnight under nitrogen. Concentrate the reaction under reduced pressure to afford the title compound (1.78 g). ES/MS m/z 133 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08759360B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-1cfc899297914db39f4a9a1200e8a672 |
| Source note | uspto-grants-2014_06 |