Hydrochloric Acid → 1-(2-Fluoroethyl)piperazine dihydrochloride

HRID 408812Notes

Reaction equation

HRID 408812 reaction equation
[ClH:1].O1CCOCC1.C(OC([N:15]1[CH2:20][CH2:19][N:18]([CH2:21][CH2:22][F:23])[CH2:17][CH2:16]1)=O)(C)(C)C>ClCCl>[ClH:1].[ClH:1].[F:23][CH2:22][CH2:21][N:18]1[CH2:19][CH2:20][NH:15][CH2:16][CH2:17]1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 312751,4-DioxaneHCID 21082715tert-Butyl 4-(2-fluoroethyl)piperazine-1-carboxylate

Product 1

HCID 665456881-(2-Fluoroethyl)piperazine dihydrochloride

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Add 4 N HCl in 1,4-dioxane (21.52 mL, 86.1 mmol) to a stirred solution of 4-(2-fluoro-ethyl)-piperazine-1-carboxylic acid tert-butyl ester (2.00 g, 8.61 mmol) in dry dichloromethane (60 mL) at room temperature under nitrogen. Stir overnight under nitrogen. Concentrate the reaction under reduced pressure to afford the title compound (1.78 g). ES/MS m/z 133 (M+1).

Workup

  1. concentrationConcentrate
  2. customthe reaction under reduced pressure

Sources & evidence

ORD record
ord-1cfc899297914db39f4a9a1200e8a672
Source dataset
uspto-grants-2014_06
Patent number
US08759360B2

Reaction notes

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