反应详情

Dissolve (2R)-2-[8-(2-chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)purin-9-yl]propan-1-ol (15.29 g, 38.14 mmol) in diethyl ether (114 mL) in a 250 mL round bottom flask, fitted with nitrogen inlet, and treat with 4 N hydrogen chloride in dioxane (9.53 mL, 38.14 mmol). Stir at room temperature for 2.5 h and then collect the solids by vacuum filtration. Wash with diethyl ether (300 mL) and then dry under vacuum to afford the title compound (12.1 g). ES/MS m/z 401.2 (M+1−HCl).

1. customfitted with nitrogen inlet
2. customcollect the solids
3. filtrationby vacuum filtration
4. washWash with diethyl ether (300 mL)
5. customdry under vacuum