反应详情

To a solution of 4-amino-3-fluorobenzoic acid (0.703 g, 4.53 mmol), N-tert-butyl-2-(piperazin-1-ylmethyl)thiazole-4-carboxamide (1.28 g, 4.53 mmol) and triethylamine (0.459 g, 4.53 mmol, 0.630 mL) in dichloromethane was added 1-propanephosphonic acid cyclic anhydride (2.88 g, 4.53 mmol, 2.70 mL, 50% solution in ethyl acetate). The reaction was concentrated under reduced pressure and the residue was taken up in ethyl acetate, washed with sodium bicarbonate (×3) and brine. The organic phase was concentrated under reduced pressure to afford the title compound (0.87 g). MS (ESI) m/z 420.3 [M+H]+

1. concentrationThe reaction was concentrated under reduced pressure
2. washwashed with sodium bicarbonate (×3) and brine
3. concentrationThe organic phase was concentrated under reduced pressure