HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → Sodium 5-((4-(tert-butoxycarbonyl)piperazin-1-yl)methyl)furan-2-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Tert-butyl 4-((5-(methoxycarbonyl)furan-2-yl)methyl)piperazine-1-carboxylate | HCID 58055786 | — |
| Product | Sodium 5-((4-(tert-butoxycarbonyl)piperazin-1-yl)methyl)furan-2-carboxylate | HCID 66661312 | 89.7% |
Reaction Steps
Tert-butyl 4-((5-(methoxycarbonyl)furan-2-yl)methyl)piperazine-1-carboxylate (4.99 g, 15.39 mmol) and sodium hydroxide (0.616 g, 15.39 mmol) were combined and stirred at reflux for 3 hours. The reaction was concentrated under reduced pressure to give the title compound (4.59 g). MS (ESI) m/z 311.4 [M+H]+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08759352B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-2fea7eac6d124c27beacf5f3087a8193 |
| Source note | uspto-grants-2014_06 |