反应详情

6-(Hydroxymethyl)picolinate (200 mg, 1.196 mmol) and triethylamine (363 mg, 3.588 mmol, 0.5 mL) were combined and stirred at 0° C. in dichloromethane (2 mL). Methanesulfonyl chloride (206 mg, 1.794 mmol) was added and the reaction allowed to warm to room temperature over 1 hour. The reaction was washed with water, dried over sodium sulfate and concentrated under vacuum to afford the title compound (293 mg). MS (ESI) m/z 246.3 [M+H]+

1. washThe reaction was washed with water
2. dry with materialdried over sodium sulfate
3. concentrationconcentrated under vacuum