反应详情

Methyl 2-(methylsulfonylmethyl)isonicotinate (2.99 mmol, 0.686 g), 1-cyclobutyl-3-(2-fluoro-4-(piperazine-1-carbonyl)phenyl)urea (2.99 mmol, 0.959 g) and potassium carbonate (8.98 mmol, 1.241 g) were combined and heated to 40° C. in acetonitrile (20 mL) for 2 hours. The reaction mixture was concentrated at reduced pressure and the residue taken up in dichloromethane. The organic phase was dried over sodium sulfate and concentrated under vacuum. The residue was purified by silica chromatography (eluting with a solvent gradient from dichloromethane to 6% methanol/dichloromethane) to afford the title compound (822 mg). MS (ESI) m/z 470.5 [M+H]+

1. concentrationThe reaction mixture was concentrated at reduced pressure
2. dry with materialThe organic phase was dried over sodium sulfate
3. concentrationconcentrated under vacuum
4. customThe residue was purified by silica chromatography (
5. washeluting with a solvent gradient from dichloromethane to 6% methanol/dichloromethane)