反应详情

Methyl 2-((4-(4-(3-cyclobutylureido)-3-fluorobenzoyl)piperazin-1-yl)methyl)isonicotinate (1.746 mmol, 0.82 g) and sodium hydroxide (1.746 mmol, 0.070 g) were heated to reflux in methanol (20 mL) for 18 hours. The reaction mixture was concentrated at reduced pressure to afford the title compound (798 mg).

1. concentrationThe reaction mixture was concentrated at reduced pressure