HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Hydroxide → Sodium 2-((4-(4-(3-cyclobutylureido)-3-fluorobenzoyl)piperazin-1-yl)methyl)isonicotinate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Hydroxide | HCID 14798 | — |
| Reactant | Methyl 2-((4-(4-(3-cyclobutylureido)-3-fluorobenzoyl)piperazin-1-yl)methyl)isonicotinate | HCID 66661722 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Sodium 2-((4-(4-(3-cyclobutylureido)-3-fluorobenzoyl)piperazin-1-yl)methyl)isonicotinate | HCID 66661564 | 95.7% |
Reaction Steps
Methyl 2-((4-(4-(3-cyclobutylureido)-3-fluorobenzoyl)piperazin-1-yl)methyl)isonicotinate (1.746 mmol, 0.82 g) and sodium hydroxide (1.746 mmol, 0.070 g) were heated to reflux in methanol (20 mL) for 18 hours. The reaction mixture was concentrated at reduced pressure to afford the title compound (798 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08759352B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-1b81ca74ec0142f385034f05e3366d19 |
| Source note | uspto-grants-2014_06 |