反应详情

Using the general procedure for synthesizing naphthyl (aminoacid ester) phosphorochloridates, the HCl salt of (S)-cyclohexyl 2-amino-2-phenylacetate (1 g), naphthalen-1-yl phosphorodichloridate (967 mg), TEA (1.03 mL) and DCM (30 mL) were combined to give (2S)-cyclohexyl-2-(chloro(naphthalen-1-yloxy)phosphorylamino)-2-phenylacetate in an 78% yield (1.32 g) as a pale yellow thick oil.

1. customfor synthesizing naphthyl (aminoacid ester) phosphorochloridates