Hydrochloric Acid → 3-(4-Fluorobenzyl)-1-methyl-6-[(1-pyridin-3-ylimidazo[1,5-a]pyridin-3-yl)carbonyl]quinazoline-2,4(1H,3H)-dione hydrochloride

HRID 409549Notes

Reaction equation

HRID 409549 reaction equation
[ClH:1].[F:2][C:3]1[CH:39]=[CH:38][C:6]([CH2:7][N:8]2[C:17](=[O:18])[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([C:19]([C:21]4[N:25]5[CH:26]=[CH:27][CH:28]=[CH:29][C:24]5=[C:23]([C:30]5[CH:31]=[N:32][CH:33]=[CH:34][CH:35]=5)[N:22]=4)=[O:20])[CH:15]=3)[N:10]([CH3:36])[C:9]2=[O:37])=[CH:5][CH:4]=1>CCOCC.CO>[ClH:1].[F:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:7][N:8]2[C:17](=[O:18])[C:16]3[C:11](=[CH:12][CH:13]=[C:14]([C:19]([C:21]4[N:25]5[CH:26]=[CH:27][CH:28]=[CH:29][C:24]5=[C:23]([C:30]5[CH:31]=[N:32][CH:33]=[CH:34][CH:35]=5)[N:22]=4)=[O:20])[CH:15]=3)[N:10]([CH3:36])[C:9]2=[O:37])=[CH:38][CH:39]=1

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 565975113-(4-Fluorobenzyl)-1-methyl-6-[(1-pyridin-3-ylimidazo[1,5-a]pyridin-3-yl)carbonyl]quinazoline-2,4(1H,3H)-dione

Product 1

HCID 866834563-(4-Fluorobenzyl)-1-methyl-6-[(1-pyridin-3-ylimidazo[1,5-a]pyridin-3-yl)carbonyl]quinazoline-2,4(1H,3H)-dione hydrochloride

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 3283Diethyl EtherSolvent

Procedure

0.35 ml (0.35 mmol) of a 1N solution of hydrochloric acid in dyethyl ether is added to 0.12 g (0.23 mmol) of 3-(4-fluorobenzyl)-1-methyl-6-[(1-pyridin-3-ylimidazo[1,5-a]pyridin-3-yl)carbonyl]quinazoline-2,4(1H,3H)-dione in 3 ml of methanol. After stirring for 1 hour at ambient temperature, the reaction medium is filtered. The precipitate obtained is rinsed with dyethyl ether, and dried under reduced pressure at 50° C. overnight. 0.12 g of a yellow solid is obtained.

Workup

  1. filtrationthe reaction medium is filtered
  2. customThe precipitate obtained
  3. washis rinsed with dyethyl ether
  4. customdried under reduced pressure at 50° C. overnight

Sources & evidence

ORD record
ord-11ca840eb4f64901b4e100a7fd00fa0b
Source dataset
uspto-grants-2014_06
Patent number
US08759344B2

Reaction notes

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