3,4-Dihydro-2-oxo-1(2H)-quinolineacetaldehyde → HCID 24802828, compound

HRID 409564Notes

Reaction equation

HRID 409564 reaction equation
Cl.[CH3:2][N:3]([CH3:19])[C:4]([C:6]1([C:12]2[CH:17]=[CH:16][C:15]([Cl:18])=[CH:14][CH:13]=2)[CH2:11][CH2:10][NH:9][CH2:8][CH2:7]1)=[O:5].[O:20]=[C:21]1[CH2:30][CH2:29][C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[N:22]1[CH2:31][CH:32]=O>>[CH3:2][N:3]([CH3:19])[C:4]([C:6]1([C:12]2[CH:13]=[CH:14][C:15]([Cl:18])=[CH:16][CH:17]=2)[CH2:7][CH2:8][N:9]([CH2:32][CH2:31][N:22]2[C:23]3[C:28](=[CH:27][CH:26]=[CH:25][CH:24]=3)[CH2:29][CH2:30][C:21]2=[O:20])[CH2:10][CH2:11]1)=[O:5]

Participants

3

Reactant 2

HCID 596622053,4-Dihydro-2-oxo-1(2H)-quinolineacetaldehydeHCID 69041672HCID 69041672, compound

Product 1

HCID 24802828HCID 24802828, compound

Procedure

Compound 115 was prepared by the same method as Compound 86 with the exception that Compound 2-3 was used instead of Compound 1-9 and that Compound 1-8 was used instead of Compound 1-4. Compound 115 was isolated as a white solid (53%, mp 243-245° C.). 1H (300 MHz, CDCl3,) δ 7.44-7.01 (m, 8H), 4.55 (m, 2H), 3.62 (m, 2H), 3.31-2.40 (m, 18H); MS (ES+) m/z 440.0 (M+1).

Sources & evidence

ORD record
ord-8d86fcb0c2bb40f3a1c2d6318fa06aa7
Source dataset
uspto-grants-2014_06
Patent number
US08759342B2

Reaction notes

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