Methanol → HCID 66895058, compound

HRID 409613Notes

Reaction equation

HRID 409613 reaction equation
[CH3:1][CH:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[N:3]1C=O.[CH:13]1([NH2:23])[C:22]2[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=2)[CH2:16][CH2:15][CH2:14]1.[CH3:24]O>>[CH3:1][CH:2]1[CH2:10][C:9]2[C:4](=[C:5]([CH:24]=[N:23][CH:13]3[C:22]4[C:17](=[CH:18][CH:19]=[CH:20][CH:21]=4)[CH2:16][CH2:15][CH2:14]3)[CH:6]=[CH:7][CH:8]=2)[NH:3]1

Participants

4

Reactant 3

HCID 887MethanolHCID 180661,2,3,4-Tetrahydro-1-naphthylamineHCID 127981582-Methyl-2,3-dihydro-1H-indole-1-carbaldehyde

Product 1

HCID 66895058HCID 66895058, compound

Procedure

1.68 g of 2-methylindolino aldehyde was dissolved in 35 ml of methanol and then 1.58 ml of 1,2,3,4-tetrahydro naphthyl amine was slowly added thereto. The mixture was stirred at room temperature overnight before some precipitates were slowly formed, and then was filtered while being washed with methanol to provide ivory solids as a clean product (2.3 g). (Yield: 75%) This compound was a mixture of two stereoisomers at a ratio of 1:0.6.

Workup

  1. customwere slowly formed
  2. filtrationwas filtered
  3. washwhile being washed with methanol

Sources & evidence

ORD record
ord-f6f7a432e2e34bf48f7216466847115b
Source dataset
uspto-grants-2014_06
Patent number
US08759461B2

Reaction notes

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