反应详情

温度

130 °C

A mixture of Compound 3 (1.0 g, 3.4 mmol) and p-toluenesulfonic acid methyl ester (0.94 g, 5.1 mmol) was heated in a pressure tube at 130° C. for 1 hour. The mixture was allowed to cool to room temperature, and the resulting mass was triturated with acetone (25 ml) until a gray colored solid separated. The solid was collected by centrifugation, washed with acetone and dried under vacuum to yield 1.4 g (86%) of Compound 4 whose structure is given below:

1. temperatureto cool to room temperature
2. customthe resulting mass was triturated with acetone (25 ml) until a gray colored solid
3. customseparated
4. customThe solid was collected by centrifugation
5. washwashed with acetone
6. customdried under vacuum