反应详情

温度

130 °C

A mixture of Compound 24 (2.0 g, 7.8 mmol) and p-toluenesulfonic acid methyl ester (2.2 g, 11.7 mmol) was heated in a pressure tube at 130° C. for 2 hours. The mixture was allowed to cool to room temperature, and the resulting mass was triturated with ethyl acetate (25 ml) until an off-white solid separated. The solid was collected by centrifugation, washed with ethyl acetate and dried under vacuum to yield 2.9 g (84%) of Compound 25 whose structure is given below:

1. temperatureto cool to room temperature
2. customthe resulting mass was triturated with ethyl acetate (25 ml) until an off-white solid
3. customseparated
4. customThe solid was collected by centrifugation
5. washwashed with ethyl acetate
6. customdried under vacuum