反应详情

410 mg (2.06 mmol) 4-(4-Ethoxy-phenyl)-pyridine in 10 mL acetic acid are hydrogenated (3 bar) for 9 h at rt using 50 mg platinum(IV) oxide. After that time, the catalyst is filtered off and the solvent is evaporated. The residue is taken up in 1N NaOH and extracted with EtOAc. The organic layer is dried over sodium sulphate and the solvent is evaporated. The residue is purified by column chromatography (silica gel; DCM:MeOH 9:1, then THF:MeOH:NH4OH 1:1:0.1) to yield the desired product.

1. customfor 9 h
2. customat rt
3. filtrationAfter that time, the catalyst is filtered off
4. customthe solvent is evaporated
5. extractionextracted with EtOAc
6. dry with materialThe organic layer is dried over sodium sulphate
7. customthe solvent is evaporated
8. customThe residue is purified by column chromatography (silica gel