Diisopropylethylamine → HCID 71576145、化合物

HRID 409738ノート

反応式

HRID 409738 の反応式
[CH3:1][NH:2][CH:3]1[CH2:7][CH2:6][CH2:5][CH2:4]1.Cl[C:9]1[N:14]=[C:13]([N:15]2[CH2:20][CH2:19][CH:18]([C:21]3[CH:26]=[CH:25][C:24]([CH:27]([CH3:33])[C:28]([NH:30][CH2:31][CH3:32])=[O:29])=[CH:23][CH:22]=3)[CH2:17][CH2:16]2)[CH:12]=[CH:11][N:10]=1.CCN(C(C)C)C(C)C>CN1C(=O)CCC1>[CH:3]1([N:2]([CH3:1])[C:9]2[N:14]=[C:13]([N:15]3[CH2:16][CH2:17][CH:18]([C:21]4[CH:26]=[CH:25][C:24]([CH:27]([CH3:33])[C:28]([NH:30][CH2:31][CH3:32])=[O:29])=[CH:23][CH:22]=4)[CH2:19][CH2:20]3)[CH:12]=[CH:11][N:10]=2)[CH2:7][CH2:6][CH2:5][CH2:4]1

参加物

5

反応物 3

HCID 81531DiisopropylethylamineHCID 7020624N-methylcyclopentanamineHCID 86686118HCID 86686118、化合物

生成物 1

HCID 71576145HCID 71576145、化合物

試薬・触媒・溶媒 1

HCID 13387N-methyl-2-pyrrolidone溶媒

反応条件

温度
120 °C

実験手順

To 26 mg (0.26 mmol) N-methyl-cyclopentylamine in 2.5 mL NMP are added 80 mg (0.22 mmol) 2-{4-[1-(2-chloro-pyrimidin-4-yl)-piperidin-4-yl]-phenyl}-N-ethyl-propion-amide (XII.1) and 110 (0.65 mmol) DIPEA. The mixture is stirred at 100° C. for 1 h and at 120° C. for 1 h under microwave irradiation. After that time, the mixture is directly purified by HPLC (XBridge 100; water, 0.3% NH4OH/MeOH) to yield the desired product.

後処理

  1. customAfter that time, the mixture is directly purified by HPLC (XBridge 100; water, 0.3% NH4OH/MeOH)

出典と根拠

ORDレコード
ord-8d8159b083b14ffb9633150b1e418dd7
出典データセット
uspto-grants-2014_06
特許番号
US08759528B2

反応ノート

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