反应详情

To 80 mg (0.22 mmol) 2-{4-[1-(2-chloro-pyrimidin-4-yl)-piperidin-4-yl]-phenyl}-N-ethyl-propionamide (XII.1) and 25 μL (0.43 mmol) ethanol in 1 mL 1,4-dioxane are added 26 mg (0.64 mmol) sodium hydride (60%) at 0° C. The mixture is stirred for 12 h at rt. After that time, the mixture is directly purified by HPLC (XBridge 10 μM; water, 0.3% NH4OH/MeOH) to yield the desired product.

1. customAfter that time, the mixture is directly purified by HPLC (XBridge 10 μM; water, 0.3% NH4OH/MeOH)