HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → Methyl 2-chloro-1,3-benzoxazole-6-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Thionyl Chloride | HCID 24386 | — |
| Reactant | HCID 178497334 | HCID 178497334 | — |
| Product | Methyl 2-chloro-1,3-benzoxazole-6-carboxylate | HCID 58433755 | — |
Reaction Steps
To Compound 4 (2 g, 9.5 mmol), SOCl2 (9.8 ml, 134 mmol) and DMF (0.8 mL, 10 mmol) was added at room temperature. The reaction mixture heated to reflux for 15 min. The solvent was removed under reduced pressure. The crude oil was azeotroped with xylene twice.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08759539B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-c894aa49e5ff4011a3709e8e3952a4d1 |
| Source note | uspto-grants-2014_06 |