反应详情

2,2-Dimethyl-propionic acid chloride (0.124 mL, 1.01 mmol) is added to a mixture of 3-nitro-2,4-dichloro-benzylamine (0.28 g, 1.01 mmol) and TEA (0.35 mL, 2.52 mmol) in THF (10 mL) and it is stirred overnight. The reaction mixture is concentrated, diluted with EtOAc, washed successively with 5% aq. NaHCO3 solution and brine, dried with Na2SO4 filtered and concentrated.

1. concentrationThe reaction mixture is concentrated
2. additiondiluted with EtOAc
3. washwashed successively with 5% aq. NaHCO3 solution and brine
4. dry with materialdried with Na2SO4
5. filtrationfiltered
6. concentrationconcentrated