Pivaloyl chloride → N-(3-amino-2,4-difluoro-benzyl)-2,2-dimethyl-propionamide

Participants

Reaction Steps

TEA (400 μL, 2.86 mmol) followed by pivaloyl chloride (60 μL, 0.52 mmol) are added to 3-aminomethyl-2,6-difluoro-aniline (120 mg as HCl salt) in THF (10 mL) and stirred at rt overnight. The reaction mixture is diluted with EtOAc and sat. NaHCO3-solution, the organic layer is washed with water and brine, dried and concentrated to give the sub-title compound.

Provenance & Evidence