反应详情

A mixture of trans-4-trifluoromethyl-cyclohexane-carboxylic acid (10.4 g, 53.1 mmol), SOCl2 (10 mL, 137 mmol), DCM (100 mL) and DMF (200 μl) is heated to reflux for 1.5 h and concentrated. The crude acid chloride is diluted with 100 mL THF and conc. NH3 (350 mL) is slowly added. It is stirred for 5 min and the mixture is concentrated and dried at 40°.

1. temperatureis heated
2. temperatureto reflux for 1.5 h
3. concentrationconcentrated
4. additionThe crude acid chloride is diluted with 100 mL THF and conc. NH3 (350 mL)
5. additionis slowly added
6. concentrationthe mixture is concentrated
7. customdried at 40°