Diisopropylcarbodiimide → HCID 178447323, compound

HRID 410090Notes

Reaction equation

HRID 410090 reaction equation
[F:1][C:2]([F:26])([F:25])[C@H:3]1[CH2:8][CH2:7][C@H:6]([NH:9][C:10](=[O:24])[C:11]2[CH:16]=[C:15]([NH2:17])[C:14]([NH2:18])=[CH:13][C:12]=2[O:19][CH2:20][CH:21]([F:23])[F:22])[CH2:5][CH2:4]1.[Cl:27][C:28]1[C:41]([N:42]=[C:43]=S)=[C:40]([Cl:45])[CH:39]=[CH:38][C:29]=1[CH2:30][NH:31][C:32](=[O:37])[C:33]([CH3:36])([CH3:35])[CH3:34].CC(C)N=C=NC(C)C>>[F:1][C:2]([F:25])([F:26])[C@H:3]1[CH2:8][CH2:7][C@H:6]([NH:9][C:10]([C:11]2[C:12]([O:19][CH2:20][CH:21]([F:22])[F:23])=[CH:13][C:14]3[NH:18][C:43]([NH:42][C:41]4[C:40]([Cl:45])=[CH:39][CH:38]=[C:29]([CH2:30][NH:31][C:32](=[O:37])[C:33]([CH3:34])([CH3:35])[CH3:36])[C:28]=4[Cl:27])=[N:17][C:15]=3[CH:16]=2)=[O:24])[CH2:5][CH2:4]1

Participants

4

Reactant 3

HCID 12734DiisopropylcarbodiimideHCID 56840192N-[(2,4-dichloro-3-isothiocyanatophenyl)methyl]-2,2-dimethylpropanamideHCID 178507938HCID 178507938, compound

Product 1

HCID 178447323HCID 178447323, compoundYield 43%

Procedure

The title compound is prepared from N-(trans-4-trifluoromethyl-cyclohex-1-yl)-2-(2,2-difluoro-ethoxy)-4,5-diamino-benzoic acid amide and N-(2,4-dichloro-3-isothiocyanato-benzyl)-2,2-dimethyl-propionamide with DIC in analogy to example 1 g.

Sources & evidence

ORD record
ord-8c6d49d1a85e4bf7be1404729f5f28ea
Source dataset
uspto-grants-2014_06
Patent number
US08759537B2

Reaction notes

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