HRID410090

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID12734

Diisopropylcarbodiimide

C7H14N2

HCID56840192

未命名化合物

结构：Nc1cc(OCC(F)F)c(C(=O)N[C@H]2CC[C@H](C(F)(F)F)CC2)cc1N

HCID178507938

未命名化合物

PRODUCTS

生成物

结构：CC(C)(C)C(=O)NCc1ccc(Cl)c(Nc2nc3cc(C(=O)N[C@H]4CC[C@H](C(F)(F)F)CC4)c(OCC(F)F)cc3[nH]2)c1Cl

HCID178447323

未命名化合物

收率 43%

PROCEDURE

实验过程

The title compound is prepared from N-(trans-4-trifluoromethyl-cyclohex-1-yl)-2-(2,2-difluoro-ethoxy)-4,5-diamino-benzoic acid amide and N-(2,4-dichloro-3-isothiocyanato-benzyl)-2,2-dimethyl-propionamide with DIC in analogy to example 1 g.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-8c6d49d1a85e4bf7be1404729f5f28ea
来源数据集: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08759537B2
来源说明: uspto-grants-2014_06

反应 SMILES

[F:1][C:2]([F:26])([F:25])[C@H:3]1[CH2:8][CH2:7][C@H:6]([NH:9][C:10](=[O:24])[C:11]2[CH:16]=[C:15]([NH2:17])[C:14]([NH2:18])=[CH:13][C:12]=2[O:19][CH2:20][CH:21]([F:23])[F:22])[CH2:5][CH2:4]1.[Cl:27][C:28]1[C:41]([N:42]=[C:43]=S)=[C:40]([Cl:45])[CH:39]=[CH:38][C:29]=1[CH2:30][NH:31][C:32](=[O:37])[C:33]([CH3:36])([CH3:35])[CH3:34].CC(C)N=C=NC(C)C>>[F:1][C:2]([F:25])([F:26])[C@H:3]1[CH2:8][CH2:7][C@H:6]([NH:9][C:10]([C:11]2[C:12]([O:19][CH2:20][CH:21]([F:22])[F:23])=[CH:13][C:14]3[NH:18][C:43]([NH:42][C:41]4[C:40]([Cl:45])=[CH:39][CH:38]=[C:29]([CH2:30][NH:31][C:32](=[O:37])[C:33]([CH3:34])([CH3:35])[CH3:36])[C:28]=4[Cl:27])=[N:17][C:15]=3[CH:16]=2)=[O:24])[CH2:5][CH2:4]1