Diisopropylcarbodiimide → HCID 178481217, compound

HRID 410092Notes

Reaction equation

HRID 410092 reaction equation
[F:1][C:2]([F:23])([F:22])[C@H:3]1[CH2:8][CH2:7][C@H:6]([NH:9][C:10](=[O:21])[C:11]2[CH:16]=[C:15]([NH2:17])[C:14]([NH:18][CH3:19])=[CH:13][C:12]=2[F:20])[CH2:5][CH2:4]1.[Cl:24][C:25]1[C:38]([N:39]=[C:40]=S)=[C:37]([Cl:42])[CH:36]=[CH:35][C:26]=1[CH2:27][NH:28][C:29](=[O:34])[C:30]([CH3:33])([CH3:32])[CH3:31].CC(C)N=C=NC(C)C>>[F:23][C:2]([F:1])([F:22])[C@H:3]1[CH2:4][CH2:5][C@H:6]([NH:9][C:10]([C:11]2[C:12]([F:20])=[CH:13][C:14]3[N:18]([CH3:19])[C:40]([NH:39][C:38]4[C:37]([Cl:42])=[CH:36][CH:35]=[C:26]([CH2:27][NH:28][C:29](=[O:34])[C:30]([CH3:33])([CH3:32])[CH3:31])[C:25]=4[Cl:24])=[N:17][C:15]=3[CH:16]=2)=[O:21])[CH2:7][CH2:8]1

Participants

4

Reactant 3

HCID 12734DiisopropylcarbodiimideHCID 56840192N-[(2,4-dichloro-3-isothiocyanatophenyl)methyl]-2,2-dimethylpropanamideHCID 178482228HCID 178482228, compound

Product 1

HCID 178481217HCID 178481217, compoundYield 60%

Procedure

The title compound is prepared from N-(trans-4-trifluoromethyl-cyclohex-1-yl)-2-fluoro-4-methylamino-5-amino-benzoic acid amide and N-(2,4-dichloro-3-isothiocyanato-benzyl)-2,2-dimethyl-propionamide with DIC in analogy to example 1g.

Sources & evidence

ORD record
ord-1e37b75fafe44fc3ac6d26f682974e0c
Source dataset
uspto-grants-2014_06
Patent number
US08759537B2

Reaction notes

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