HRID410092

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID12734

Diisopropylcarbodiimide

C7H14N2

HCID56840192

未命名化合物

结构：CNc1cc(F)c(C(=O)N[C@H]2CC[C@H](C(F)(F)F)CC2)cc1N

HCID178482228

未命名化合物

PRODUCTS

生成物

结构：Cn1c(Nc2c(Cl)ccc(CNC(=O)C(C)(C)C)c2Cl)nc2cc(C(=O)N[C@H]3CC[C@H](C(F)(F)F)CC3)c(F)cc21

HCID178481217

未命名化合物

收率 60%

PROCEDURE

实验过程

The title compound is prepared from N-(trans-4-trifluoromethyl-cyclohex-1-yl)-2-fluoro-4-methylamino-5-amino-benzoic acid amide and N-(2,4-dichloro-3-isothiocyanato-benzyl)-2,2-dimethyl-propionamide with DIC in analogy to example 1g.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1e37b75fafe44fc3ac6d26f682974e0c
来源数据集: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
专利: US08759537B2
来源说明: uspto-grants-2014_06

反应 SMILES

[F:1][C:2]([F:23])([F:22])[C@H:3]1[CH2:8][CH2:7][C@H:6]([NH:9][C:10](=[O:21])[C:11]2[CH:16]=[C:15]([NH2:17])[C:14]([NH:18][CH3:19])=[CH:13][C:12]=2[F:20])[CH2:5][CH2:4]1.[Cl:24][C:25]1[C:38]([N:39]=[C:40]=S)=[C:37]([Cl:42])[CH:36]=[CH:35][C:26]=1[CH2:27][NH:28][C:29](=[O:34])[C:30]([CH3:33])([CH3:32])[CH3:31].CC(C)N=C=NC(C)C>>[F:23][C:2]([F:1])([F:22])[C@H:3]1[CH2:4][CH2:5][C@H:6]([NH:9][C:10]([C:11]2[C:12]([F:20])=[CH:13][C:14]3[N:18]([CH3:19])[C:40]([NH:39][C:38]4[C:37]([Cl:42])=[CH:36][CH:35]=[C:26]([CH2:27][NH:28][C:29](=[O:34])[C:30]([CH3:33])([CH3:32])[CH3:31])[C:25]=4[Cl:24])=[N:17][C:15]=3[CH:16]=2)=[O:21])[CH2:7][CH2:8]1