N-(4-bromophenyl)-2-(2,2-difluoroethoxy)-4-(methylamino)-5-nitrobenzamide → 5-amino-N-(4-bromophenyl)-2-(2,2-difluoroethoxy)-4-(methylamino)benzamide

HRID 410101Notes

Reaction equation

HRID 410101 reaction equation
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8][C:9](=[O:26])[C:10]2[CH:15]=[C:14]([N+:16]([O-])=O)[C:13]([NH:19][CH3:20])=[CH:12][C:11]=2[O:21][CH2:22][CH:23]([F:25])[F:24])=[CH:4][CH:3]=1>[Ni]>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([NH:8][C:9](=[O:26])[C:10]2[CH:15]=[C:14]([NH2:16])[C:13]([NH:19][CH3:20])=[CH:12][C:11]=2[O:21][CH2:22][CH:23]([F:25])[F:24])=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 59529852N-(4-bromophenyl)-2-(2,2-difluoroethoxy)-4-(methylamino)-5-nitrobenzamide

Product 1

HCID 595298615-amino-N-(4-bromophenyl)-2-(2,2-difluoroethoxy)-4-(methylamino)benzamide

Reagents, catalysts & solvents 1

HCID 935NickelCatalyst

Procedure

The subtitle compound is prepared from N-(4-bromophenyl)-2-(2,2-difluoro-ethoxy)-4-methylamino-5-nitro-benzamide, RaNi and H2 in analogy to example 5c.

Sources & evidence

ORD record
ord-e2a656c156324efb8069b241f76b1020
Source dataset
uspto-grants-2014_06
Patent number
US08759537B2

Reaction notes

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