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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 410101Generated: October 29, 2026

N-(4-bromophenyl)-2-(2,2-difluoroethoxy)-4-(methylamino)-5-nitrobenzamide → 5-amino-N-(4-bromophenyl)-2-(2,2-difluoroethoxy)-4-(methylamino)benzamide

https://huagongshe.com/reaction/410101

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN-(4-bromophenyl)-2-(2,2-difluoroethoxy)-4-(methylamino)-5-nitrobenzamideHCID 59529852—
CatalystNickelHCID 935—
Product5-amino-N-(4-bromophenyl)-2-(2,2-difluoroethoxy)-4-(methylamino)benzamideHCID 59529861—

Reaction Steps

The subtitle compound is prepared from N-(4-bromophenyl)-2-(2,2-difluoro-ethoxy)-4-methylamino-5-nitro-benzamide, RaNi and H2 in analogy to example 5c.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08759537B2
Source datasetuspto-grants-2014_06
ORD IDord-e2a656c156324efb8069b241f76b1020
Source noteuspto-grants-2014_06