Diisopropylcarbodiimide → HCID 178447322, compound

HRID 410108Notes

Reaction equation

HRID 410108 reaction equation
[F:1][C:2]([F:22])([F:21])[C@H:3]1[CH2:8][CH2:7][C@H:6]([NH:9][C:10](=[O:20])[C:11]2[CH:16]=[C:15]([NH2:17])[C:14]([NH2:18])=[CH:13][C:12]=2[F:19])[CH2:5][CH2:4]1.[Cl:23][C:24]1[C:37]([N:38]=[C:39]=S)=[C:36]([Cl:41])[CH:35]=[CH:34][C:25]=1[CH2:26][NH:27][C:28](=[O:33])[C:29]([CH3:32])([CH3:31])[CH3:30].CC(C)N=C=NC(C)C>>[F:22][C:2]([F:1])([F:21])[C@H:3]1[CH2:4][CH2:5][C@H:6]([NH:9][C:10]([C:11]2[C:12]([F:19])=[CH:13][C:14]3[NH:18][C:39]([NH:38][C:37]4[C:36]([Cl:41])=[CH:35][CH:34]=[C:25]([CH2:26][NH:27][C:28](=[O:33])[C:29]([CH3:30])([CH3:31])[CH3:32])[C:24]=4[Cl:23])=[N:17][C:15]=3[CH:16]=2)=[O:20])[CH2:7][CH2:8]1

Participants

4

Reactant 3

HCID 12734DiisopropylcarbodiimideHCID 56840192N-[(2,4-dichloro-3-isothiocyanatophenyl)methyl]-2,2-dimethylpropanamideHCID 178507810HCID 178507810, compound

Product 1

HCID 178447322HCID 178447322, compound

Procedure

The title compound is prepared from N-(trans-4-trifluoromethyl-cyclohex-1-yl)-2-fluoro-4,5-diamino-benzoic acid amide and N-(2,4-dichloro-3-isothiocyanato-benzyl)-2,2-dimethyl-propionamide with DIC in analogy to examples 7b/7c.

Sources & evidence

ORD record
ord-a30336f9c48f4338ab037482ab7b61ce
Source dataset
uspto-grants-2014_06
Patent number
US08759537B2

Reaction notes

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