反应详情

3-(Trifluoromethyl)benzaldehyde (100 g) was added to a pre-cooled (0 to 5° C.) solution of vinyl magnesium bromide (862 mL; 1M) in tetrahydrofuran under the nitrogen atmosphere. The reaction mixture was stirred at room-temperature for one hour. After completion, the reaction was quenched with de-ionized water (500 mL) and dichloromethane (500 mL) was added. The dichloromethane layer was washed with sodium bicarbonate solution (7%; 500 mL), layers were separated and organic layer was concentrated under vacuum at 40° C. to 45° C. to give 1-[3-(trifluoromethyl)phenyl]prop-2-en-1-ol as oil.

1. customAfter completion, the reaction was quenched with de-ionized water (500 mL) and dichloromethane (500 mL)
2. additionwas added
3. washThe dichloromethane layer was washed with sodium bicarbonate solution (7%; 500 mL), layers
4. customwere separated
5. concentrationorganic layer was concentrated under vacuum at 40° C. to 45° C.