(1H-benzo[d]imidazol-2-yl)(4-hydroxyphenyl)methanone → 4-(2-(4-(1H-Benzo[D]imidazole-2-carbonyl)phenoxy)pyridin-3-YL)-1-methylpiperidin-2-one

HRID 410262Notes

Reaction equation

HRID 410262 reaction equation
F[C:2]1[C:7]([CH:8]2[CH2:13][CH2:12][N:11]([CH3:14])[C:10](=[O:15])[CH2:9]2)=[CH:6][CH:5]=[CH:4][N:3]=1.[NH:16]1[C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=2[N:18]=[C:17]1[C:25]([C:27]1[CH:32]=[CH:31][C:30]([OH:33])=[CH:29][CH:28]=1)=[O:26]>>[NH:16]1[C:20]2[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=2[N:18]=[C:17]1[C:25]([C:27]1[CH:32]=[CH:31][C:30]([O:33][C:2]2[C:7]([CH:8]3[CH2:13][CH2:12][N:11]([CH3:14])[C:10](=[O:15])[CH2:9]3)=[CH:6][CH:5]=[CH:4][N:3]=2)=[CH:29][CH:28]=1)=[O:26]

Participants

3

Reactant 2

HCID 59326874(1H-benzo[d]imidazol-2-yl)(4-hydroxyphenyl)methanoneHCID 593270104-(2-Fluoropyridin-3-yl)-1-methylpiperidin-2-one

Product 1

HCID 593271374-(2-(4-(1H-Benzo[D]imidazole-2-carbonyl)phenoxy)pyridin-3-YL)-1-methylpiperidin-2-one

Procedure

The title compound was prepared from 4-(2-fluoropyridin-3-yl)-1-methylpiperidin-2-one (Step 3, Example 1) and (1H-benzo[d]imidazol-2-yl)(4-hydroxyphenyl)methanone by following the procedure described in Step 4 of Example 1. MS (ESI, pos. ion) m/z: 427.1 (M+1). IC50 (uM) +++++.

Sources & evidence

ORD record
ord-d3c71f44fb2e40b0897529e61193021a
Source dataset
uspto-grants-2014_06
Patent number
US08759532B2

Reaction notes

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