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(1H-benzo[d]imidazol-2-yl)(4-hydroxyphenyl)methanone → 4-(2-(4-(1H-Benzo[D]imidazole-2-carbonyl)phenoxy)pyridin-3-YL)-1-methylpiperidin-2-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | (1H-benzo[d]imidazol-2-yl)(4-hydroxyphenyl)methanone | HCID 59326874 | — |
| 反応物 | 4-(2-Fluoropyridin-3-yl)-1-methylpiperidin-2-one | HCID 59327010 | — |
| 生成物 | 4-(2-(4-(1H-Benzo[D]imidazole-2-carbonyl)phenoxy)pyridin-3-YL)-1-methylpiperidin-2-one | HCID 59327137 | — |
反応手順
The title compound was prepared from 4-(2-fluoropyridin-3-yl)-1-methylpiperidin-2-one (Step 3, Example 1) and (1H-benzo[d]imidazol-2-yl)(4-hydroxyphenyl)methanone by following the procedure described in Step 4 of Example 1. MS (ESI, pos. ion) m/z: 427.1 (M+1). IC50 (uM) +++++.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08759532B2 |
| 出典データセット | uspto-grants-2014_06 |
| ORD ID | ord-d3c71f44fb2e40b0897529e61193021a |
| 出典メモ | uspto-grants-2014_06 |