1,1-Dimethylethyl N-[2-[(3-chlorophenyl)amino]-2-oxoethyl]carbamate → HCID 22690363, compound

HRID 410352Notes

Reaction equation

HRID 410352 reaction equation
C(OC(=O)[NH:7][CH2:8][C:9](=[O:18])[NH:10][C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([Cl:17])[CH:12]=1)(C)(C)C>Cl.O1CCOCC1>[NH2:7][CH2:8][C:9]([NH:10][C:11]1[CH:16]=[CH:15][CH:14]=[C:13]([Cl:17])[CH:12]=1)=[O:18]

Participants

3

Reactant 1

HCID 474512211,1-Dimethylethyl N-[2-[(3-chlorophenyl)amino]-2-oxoethyl]carbamate

Product 1

HCID 22690363HCID 22690363, compound

Reagents, catalysts & solvents 1

HCID 204431481,4-Dioxane hydrochlorideSolvent

Procedure

To [(3-chloro-phenylcarbamoyl)-methyl]-carbamic acid tert-butyl ester (0.7 g, 2.46 mmol) at rt was added 1,4-dioxane HCl (10 ml). The reaction was stirred for 16 h at rt and then filtered. The collected solid was 2-amino-N-(3-chloro-phenyl)-acetamide hydrochloride salt (0.6 g, 100%). HPLC-MS 184, 186 [M+1]+.

Workup

  1. filtrationfiltered

Sources & evidence

ORD record
ord-a50d544c6ad54c9fb9f0154be8cc1a15
Source dataset
uspto-grants-2014_06
Patent number
US08759520B2

Reaction notes

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