Lithium Hydroxide → HCID 53356439, compound

HRID 410753Notes

Reaction equation

HRID 410753 reaction equation
C[O:2][C:3]([C:5]1[CH:26]=[CH:25][C:8]2[N:9]([CH3:24])[C:10]([NH:12][C:13]3[S:14][C:15]4[CH:21]=[C:20]([F:22])[C:19]([F:23])=[CH:18][C:16]=4[N:17]=3)=[N:11][C:7]=2[CH:6]=1)=[O:4].[OH-].[Li+]>>[F:23][C:19]1[C:20]([F:22])=[CH:21][C:15]2[S:14][C:13]([NH:12][C:10]3[N:9]([CH3:24])[C:8]4[CH:25]=[CH:26][C:5]([C:3]([OH:4])=[O:2])=[CH:6][C:7]=4[N:11]=3)=[N:17][C:16]=2[CH:18]=1

Participants

3

Reactant 2

HCID 3939Lithium HydroxideHCID 53356441HCID 53356441, compound

Product 1

HCID 53356439HCID 53356439, compoundYield 47.6%

Procedure

2-(5,6-Difluoro-benzothiazol-2-ylamino)-1-methyl-1H-benzoimidazole-5-carboxylic acid (265 mg) was prepared by following General Procedure E starting from 2-(5,6-difluoro-benzothiazol-2-ylamino)-1-methyl-1H-benzoimidazole-5-carboxylic acid methyl ester (579 mg) and lithium hydroxide (260 mg). LC/MS: m/z 361.9. 1H NMR (DMSO-d6, 400 MHz): δ 12.75 (bs, 1H), 12.35 (bs, 1H), 8.15 (s, 1H), 7.96 (t, 1H), 7.85 (d, 1H), 7.57 (s, 1H), 7.48 (d, 1H), 3.62 (bs, 3H).

Sources & evidence

ORD record
ord-8ba717872450476287d942eedc3c7983
Source dataset
uspto-grants-2014_06
Patent number
US08759535B2

Reaction notes

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