N-methyl-3-(methylamino)-4-nitrobenzamide → 4-Amino-N-methyl-3-methylamino-benzamide

HRID 410759Notes

Reaction equation

HRID 410759 reaction equation
[CH3:1][NH:2][C:3](=[O:15])[C:4]1[CH:9]=[CH:8][C:7]([N+:10]([O-])=O)=[C:6]([NH:13][CH3:14])[CH:5]=1>[Pd]>[NH2:10][C:7]1[CH:8]=[CH:9][C:4]([C:3]([NH:2][CH3:1])=[O:15])=[CH:5][C:6]=1[NH:13][CH3:14]

Participants

3

Reactant 1

HCID 60144426N-methyl-3-(methylamino)-4-nitrobenzamide

Product 1

HCID 633568544-Amino-N-methyl-3-methylamino-benzamideYield 86%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

4-Amino-N-methyl-3-methylamino-benzamide (298 mg, 86%) was prepared by following General Procedure B starting from N-methyl-3-methylamino-4-nitro-benzamide (407 mg) and Pd/C (10% by weight, 40 mg). The crude product was used directly in the next step.

Sources & evidence

ORD record
ord-b8c3d3a900554788a3e1c78cbe6c3a48
Source dataset
uspto-grants-2014_06
Patent number
US08759535B2

Reaction notes

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