HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methoxyethylamine → 2-Fluoro-N-(2-methoxy-ethyl)-4-methylamino-5-nitro-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methoxyethylamine | HCID 8018 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((1H-benzotriazol-1-yloxy)(dimethylamino)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 2733084 | — |
| Reactant | 2-Fluoro-4-(methylamino)-5-nitrobenzoic acid | HCID 59529834 | — |
| Product | 2-Fluoro-N-(2-methoxy-ethyl)-4-methylamino-5-nitro-benzamide | HCID 67335417 | — |
Reaction Steps
2-Fluoro-N-(2-methoxy-ethyl)-4-methylamino-5-nitro-benzamide was prepared by following General Procedure F starting from 2-fluoro-4-methylamino-5-nitro-benzoic acid (75 mg), HBTU (159 mg), DIEA (92 uL), and 2-methoxyethylamine (26 mg). The crude product was used directly in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08759535B2 |
| Source dataset | uspto-grants-2014_06 |
| ORD ID | ord-13fdf144382647c19a373ff3076c8d39 |
| Source note | uspto-grants-2014_06 |