2-Fluoro-N-(2-methoxy-ethyl)-4-methylamino-5-nitro-benzamide → 5-Amino-2-fluoro-N-(2-methoxy-ethyl)-4-methylamino-benzamide

HRID 410763Notes

Reaction equation

HRID 410763 reaction equation
[F:1][C:2]1[CH:14]=[C:13]([NH:15][CH3:16])[C:12]([N+:17]([O-])=O)=[CH:11][C:3]=1[C:4]([NH:6][CH2:7][CH2:8][O:9][CH3:10])=[O:5]>[Pd]>[NH2:17][C:12]1[C:13]([NH:15][CH3:16])=[CH:14][C:2]([F:1])=[C:3]([CH:11]=1)[C:4]([NH:6][CH2:7][CH2:8][O:9][CH3:10])=[O:5]

Participants

3

Reactant 1

HCID 673354172-Fluoro-N-(2-methoxy-ethyl)-4-methylamino-5-nitro-benzamide

Product 1

HCID 673333195-Amino-2-fluoro-N-(2-methoxy-ethyl)-4-methylamino-benzamide

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

5-Amino-2-fluoro-N-(2-methoxy-ethyl)-4-methylamino-benzamide (72 mg) was prepared by following General Procedure B starting from 2-fluoro-N-(2-methoxy-ethyl)-4-methylamino-5-nitro-benzamide and Pd/C (10% by weight, 10 mg). Th crude product was used in the next step without further purification.

Workup

  1. customTh crude product was used in the next step without further purification

Sources & evidence

ORD record
ord-cdb74bf054ce4606becf3b04888d648e
Source dataset
uspto-grants-2014_06
Patent number
US08759535B2

Reaction notes

Loading…