HCID 59395139, compound → HCID 67333436, compound

HRID 410766Notes

Reaction equation

HRID 410766 reaction equation
[CH3:1][O:2][C:3](=[O:16])[C:4]1[CH:9]=[C:8]([N+:10]([O-])=O)[C:7]([NH:13][CH3:14])=[CH:6][C:5]=1[F:15]>[Pd]>[CH3:1][O:2][C:3](=[O:16])[C:4]1[CH:9]=[C:8]([NH2:10])[C:7]([NH:13][CH3:14])=[CH:6][C:5]=1[F:15]

Participants

3

Reactant 1

HCID 59395139HCID 59395139, compound

Product 1

HCID 67333436HCID 67333436, compoundYield 88.3%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

5-Amino-2-fluoro-4-methylamino-benzoic acid methyl ester (115 mg) was prepared by following General Procedure B starting from 2-fluoro-4-methylamino-5-nitro-benzoic acid methyl ester (150 mg) and Pd/C (10% by weight, 15 mg). The crude product was used in the next step without further purification.

Workup

  1. customThe crude product was used in the next step without further purification

Sources & evidence

ORD record
ord-bb4a58489da942f2b8b4ab9e3527896c
Source dataset
uspto-grants-2014_06
Patent number
US08759535B2

Reaction notes

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