huagongshe.com
HRID410767

反应详情

EQUATION

反应方程式

HRID 410767 的结构方程式

REACTANTS

反应物

3
结构：Nc1nc2ccc(OC(F)(F)F)cc2s1
HCID5070

6-(Trifluoromethoxy)-2-Benzothiazolamine

C8H5F3N2OS

结构：S=C(n1ccnc1)n1ccnc1
HCID80264

Thiocarbonyldiimidazole

C7H6N4S

结构：CNc1cc(F)c(C(=O)OC)cc1N
HCID67333436

未命名化合物

PRODUCTS

生成物

1
结构：COC(=O)c1cc2nc(Nc3nc4ccc(OC(F)(F)F)cc4s3)n(C)c2cc1F
HCID58397640

未命名化合物

收率 64.7%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：ClCCCl
溶剂HCID11

1,2-Dichloroethane

C2H4Cl2

PROCEDURE

实验过程

6-Fluoro-1-methyl-2-(6-trifluoromethoxy-benzothiazol-2-ylamino)-1H-benzoimidazole-5-carboxylic acid methyl ester (140 mg) was prepared by following General Procedure D starting from 5-amino-2-fluoro-4-methylamino-benzoic acid methyl ester (115 mg), 2-amino-6-(trifluoromethoxy)benzothiazole (115 mg), 1,1′-thiocarbonyldiimidazole (126 mg), and EDC (153 mg). LC/MS: m/z 441.8.