Lithium Hydroxide → HCID 86656803, compound

HRID 410809Notes

Reaction equation

C[O:2][C:3](=[O:33])[CH2:4][NH:5][C:6]([C:8]1[CH:32]=[CH:31][C:11]2[N:12]([CH3:30])[C:13]([NH:15][C:16]3[S:17][C:18]4[CH:24]=[C:23]([O:25][C:26]([F:29])([F:28])[F:27])[CH:22]=[CH:21][C:19]=4[N:20]=3)=[N:14][C:10]=2[CH:9]=1)=[O:7].[Li+].[OH-]>>[CH3:30][N:12]1[C:11]2[CH:31]=[CH:32][C:8]([C:6]([NH:5][CH2:4][C:3]([OH:33])=[O:2])=[O:7])=[CH:9][C:10]=2[N:14]=[C:13]1[NH:15][C:16]1[S:17][C:18]2[CH:24]=[C:23]([O:25][C:26]([F:29])([F:28])[F:27])[CH:22]=[CH:21][C:19]=2[N:20]=1

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 86656799HCID 86656799, compound

Product 1

HCID 86656803HCID 86656803, compoundYield 90.6%

Procedure

{[1-Methyl-2-(6-trifluoromethoxy-benzothiazol-2-ylamino)-1H-benzoimidazole-5-carbonyl]-amino}-acetic acid (211 mg) was prepared by following General Procedure E starting from {[1-Methyl-2-(6-trifluoromethoxy-benzothiazol-2-ylamino)-1H-benzoimidazole-5-carbonyl]-amino}-acetic acid methyl ester (240 mg), and LiOH (1.0 ml, 2.0 N solution in water). LC/MS: m/z 467.

Sources & evidence

ORD record: ord-a3b191fd8cff4bb2941a3078770785f6
Source dataset: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08759535B2

Reaction notes

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