Hydrochloric Acid → HCID 86656810, compound

HRID 410819Notes

Reaction equation

HRID 410819 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]([C:17]2[CH:41]=[CH:40][C:20]3[N:21]([CH3:39])[C:22]([NH:24][C:25]4[S:26][C:27]5[CH:33]=[C:32]([O:34][C:35]([F:38])([F:37])[F:36])[CH:31]=[CH:30][C:28]=5[N:29]=4)=[N:23][C:19]=3[CH:18]=2)=[O:16])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:42]>>[ClH:42].[NH:8]1[CH2:9][CH2:10][CH:11]([NH:14][C:15]([C:17]2[CH:41]=[CH:40][C:20]3[N:21]([CH3:39])[C:22]([NH:24][C:25]4[S:26][C:27]5[CH:33]=[C:32]([O:34][C:35]([F:37])([F:36])[F:38])[CH:31]=[CH:30][C:28]=5[N:29]=4)=[N:23][C:19]=3[CH:18]=2)=[O:16])[CH2:12][CH2:13]1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 86656809HCID 86656809, compound

Product 1

HCID 86656810HCID 86656810, compound

Procedure

1-Methyl-2-(6-trifluoromethoxy-benzothiazol-2-ylamino)-1H-benzoimidazole-5-carboxylic acid piperidin-4-ylamide hydrochloride (15 mg) was prepared by following General Procedure L using 4-{[1-methyl-2-(6-trifluoromethoxy-benzothiazol-2-ylamino)-1H-benzoimidazole-5-carbonyl]-amino}-piperidine-1-carboxylic acid tert-butyl ester (30 mg), and hydrochloric acid (0.1 ml, 4.0 N solution in dioxane). LC/MS: m/z 492. 1H NMR (DMSO-d6, 400 MHz): δ 9.21 (br, 1H), 9.00 (br, 1H), 8.42 (m, 1H), 8.06 (s, 1H), 7.90 (s, 1H), 7.72 (br, 1H), 7.45 (d, 1H), 7.36 (d, 1H), 3.52 (s, 3H), 3.32 (m, 4H), 2.92 (q, 4H), and 1.79 (m, 2H).

Sources & evidence

ORD record
ord-b35a3a0649e54b5590122da51bef3561
Source dataset
uspto-grants-2014_06
Patent number
US08759535B2

Reaction notes

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