Hydrochloric Acid → HCID 86656813, compound

HRID 410821Notes

Reaction equation

C(OC([N:8]1[CH2:13][CH2:12][CH2:11][CH:10]([NH:14][C:15]([C:17]2[CH:41]=[CH:40][C:20]3[N:21]([CH3:39])[C:22]([NH:24][C:25]4[S:26][C:27]5[CH:33]=[C:32]([O:34][C:35]([F:38])([F:37])[F:36])[CH:31]=[CH:30][C:28]=5[N:29]=4)=[N:23][C:19]=3[CH:18]=2)=[O:16])[CH2:9]1)=O)(C)(C)C.[ClH:42]>>[ClH:42].[NH:8]1[CH2:13][CH2:12][CH2:11][CH:10]([NH:14][C:15]([C:17]2[CH:41]=[CH:40][C:20]3[N:21]([CH3:39])[C:22]([NH:24][C:25]4[S:26][C:27]5[CH:33]=[C:32]([O:34][C:35]([F:36])([F:38])[F:37])[CH:31]=[CH:30][C:28]=5[N:29]=4)=[N:23][C:19]=3[CH:18]=2)=[O:16])[CH2:9]1

Participants

Reactant 2

HCID 313Hydrochloric Acid

HCID 86656812HCID 86656812, compound

Product 1

HCID 86656813HCID 86656813, compound

Procedure

1-Methyl-2-(6-trifluoromethoxy-benzothiazol-2-ylamino)-1H-benzoimidazole-5-carboxylic acid piperidin-3-ylamide hydrochloride (13 mg) was prepared by following General Procedure L using 3-{[1-methyl-2-(6-trifluoromethoxy-benzothiazol-2-ylamino)-1H-benzoimidazole-5-carbonyl]-amino}-piperidine-1-carboxylic acid tert-butyl ester (30 mg), and hydrochloric acid (0.1 ml, 4.0 N solution dioxane). LC/MS: m/z 492.

Sources & evidence

ORD record: ord-c97c401866b34be5b94d1ad9d24ca396
Source dataset: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08759535B2

Reaction notes

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