反应详情

An ice-cooled solution of 2.0 g (9.92 mmol) of N-allyl-5-chloro-2-thiophenecarboxamide in 10 ml of dichloromethane is admixed with metachloroperbenzoic acid (3.83 g, about 60% strength). The mixture is stirred overnight, during which it is allowed to warm to room temperature, and is then washed with 10% sodium hydrogen sulphate solution (three times). The organic phase is washed with saturated sodium bicarbonate solution (twice) and with saturated sodium chloride solution, dried over magnesium sulphate and concentrated. The product is purified by silica gel chromatography (cyclohexane/ethyl acetate 1:1).

1. washis then washed with 10% sodium hydrogen sulphate solution (three times)
2. washThe organic phase is washed with saturated sodium bicarbonate solution (twice) and with saturated sodium chloride solution
3. dry with materialdried over magnesium sulphate
4. concentrationconcentrated
5. customThe product is purified by silica gel chromatography (cyclohexane/ethyl acetate 1:1)