Lithium Hydroxide → 2-(5-Fluoro-benzothiazol-2-ylamino)-1-methyl-1H-benzimidazole-5-carboxylic acid

HRID 410850Notes

Reaction equation

HRID 410850 reaction equation
C[O:2][C:3]([C:5]1[CH:25]=[CH:24][C:8]2[N:9]([CH3:23])[C:10]([NH:12][C:13]3[S:14][C:15]4[CH:21]=[CH:20][C:19]([F:22])=[CH:18][C:16]=4[N:17]=3)=[N:11][C:7]=2[CH:6]=1)=[O:4].[Li+].[OH-]>>[F:22][C:19]1[CH:20]=[CH:21][C:15]2[S:14][C:13]([NH:12][C:10]3[N:9]([CH3:23])[C:8]4[CH:24]=[CH:25][C:5]([C:3]([OH:4])=[O:2])=[CH:6][C:7]=4[N:11]=3)=[N:17][C:16]=2[CH:18]=1

Participants

3

Reactant 2

HCID 3939Lithium HydroxideHCID 583974762-(5-fluoro-benzothiazol-2-ylamino)-1-methyl-1H-benzimidazole-5-carboxylic acid methyl ester

Product 1

HCID 583975922-(5-Fluoro-benzothiazol-2-ylamino)-1-methyl-1H-benzimidazole-5-carboxylic acidYield 89.5%

Procedure

2-(5-Fluoro-benzothiazol-2-ylamino)-1-methyl-1H-benzimidazole-5-carboxylic acid (1.53 g) was prepared by following General Procedure E starting from 2-(5-fluoro-benzothiazol-2-ylamino)-1-methyl-1H-benzimidazole-5-carboxylic acid methyl ester (1.78 g), and LiOH (10.0 ml, 2.0 N solution in water). LC/MS: m/z 344.

Sources & evidence

ORD record
ord-93b81e0819ab460b96d9eca25992ea3f
Source dataset
uspto-grants-2014_06
Patent number
US08759535B2

Reaction notes

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