Lithium Hydroxide → HCID 58397623, compound

HRID 410853Notes

Reaction equation

HRID 410853 reaction equation
C[O:2][C:3]([C:5]1[CH:25]=[CH:24][C:8]2[N:9]([CH3:23])[C:10]([NH:12][C:13]3[S:14][C:15]4[CH:21]=[C:20]([CH3:22])[CH:19]=[CH:18][C:16]=4[N:17]=3)=[N:11][C:7]=2[CH:6]=1)=[O:4].[Li+].[OH-]>>[CH3:23][N:9]1[C:8]2[CH:24]=[CH:25][C:5]([C:3]([OH:4])=[O:2])=[CH:6][C:7]=2[N:11]=[C:10]1[NH:12][C:13]1[S:14][C:15]2[CH:21]=[C:20]([CH3:22])[CH:19]=[CH:18][C:16]=2[N:17]=1

Participants

3

Reactant 2

HCID 3939Lithium HydroxideHCID 583976271-methyl-2-(6-methyl-benzothiazol-2-ylamino)-1H-benzimidazole-5-carboxylic acid methyl ester

Product 1

HCID 58397623HCID 58397623, compoundYield 91.7%

Procedure

1-Methyl-2-(6-methyl-benzothiazol-2-ylamino)-1H-benzimidazole-5-carboxylic acid (1.55 g) was prepared by following General Procedure E starting from 1-methyl-2-(6-methyl-benzothiazol-2-ylamino)-1H-benzimidazole-5-carboxylic acid methyl ester (1.76 g), and LiOH (10.0 ml, 2.0 N solution in water). LC/MS: m/z 340.

Sources & evidence

ORD record
ord-2a0491d3ff58448f86a52c0a32f9218f
Source dataset
uspto-grants-2014_06
Patent number
US08759535B2

Reaction notes

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