Lithium Hydroxide → HCID 58397518, compound

HRID 410876Notes

Reaction equation

C[O:2][C:3](=[O:34])[C@@H:4]([NH:6][C:7]([C:9]1[CH:33]=[CH:32][C:12]2[N:13]([CH3:31])[C:14]([NH:16][C:17]3[S:18][C:19]4[CH:25]=[C:24]([O:26][C:27]([F:30])([F:29])[F:28])[CH:23]=[CH:22][C:20]=4[N:21]=3)=[N:15][C:11]=2[CH:10]=1)=[O:8])[CH3:5].[Li+].[OH-]>>[CH3:31][N:13]1[C:12]2[CH:32]=[CH:33][C:9]([C:7]([NH:6][C@@H:4]([CH3:5])[C:3]([OH:34])=[O:2])=[O:8])=[CH:10][C:11]=2[N:15]=[C:14]1[NH:16][C:17]1[S:18][C:19]2[CH:25]=[C:24]([O:26][C:27]([F:30])([F:29])[F:28])[CH:23]=[CH:22][C:20]=2[N:21]=1

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 58397489HCID 58397489, compound

Product 1

HCID 58397518HCID 58397518, compoundYield 86.3%

Procedure

(S)-2-{[1-Methyl-2-(6-trifluoromethoxy-benzothiazol-2-ylamino)-1H-benzo-imidazole-5-carbonyl]-amino}-propionic acid (83 mg) was prepared by following General Procedure E starting from (S)-2-{[1-methyl-2-(6-trifluoromethoxy-benzothiazol-2-ylamino)-1H-benzoimidazole-5-carbonyl]-amino}-propionic acid methyl ester (99 mg), and LiOH (0.5 ml, 2.0 N solution in water). LC/MS: m/z 481.

Sources & evidence

ORD record: ord-1b64a8e95f124204b855dce68ab18878
Source dataset: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08759535B2

Reaction notes

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