Lithium Hydroxide → HCID 58397772, compound

HRID 410877Notes

Reaction equation

C([O:3][C:4]([C:6]1([NH:9][C:10]([C:12]2[CH:36]=[CH:35][C:15]3[N:16]([CH3:34])[C:17]([NH:19][C:20]4[S:21][C:22]5[CH:28]=[C:27]([O:29][C:30]([F:33])([F:32])[F:31])[CH:26]=[CH:25][C:23]=5[N:24]=4)=[N:18][C:14]=3[CH:13]=2)=[O:11])[CH2:8][CH2:7]1)=[O:5])C.[Li+].[OH-]>>[CH3:34][N:16]1[C:15]2[CH:35]=[CH:36][C:12]([C:10]([NH:9][C:6]3([C:4]([OH:5])=[O:3])[CH2:8][CH2:7]3)=[O:11])=[CH:13][C:14]=2[N:18]=[C:17]1[NH:19][C:20]1[S:21][C:22]2[CH:28]=[C:27]([O:29][C:30]([F:32])([F:31])[F:33])[CH:26]=[CH:25][C:23]=2[N:24]=1

Participants

Reactant 2

HCID 3939Lithium Hydroxide

HCID 58397756HCID 58397756, compound

Product 1

HCID 58397772HCID 58397772, compoundYield 92.5%

Procedure

1-{[1-Methyl-2-(6-trifluoromethoxy-benzothiazol-2-ylamino)-1H-benzimidazole-5-carbonyl]-amino}-cyclopropanecarboxylic acid (91 mg) was prepared by following General Procedure E starting from 1-{[1-methyl-2-(6-trifluoromethoxy-benzothiazol-2-ylamino)-1H-benzimidazole-5-carbonyl]-amino}-cyclopropanecarboxylic acid ethyl ester (104 mg), and LiOH (0.5 ml, 2.0 N solution in water). LC/MS: m/z 493.

Sources & evidence

ORD record: ord-6d9dd0caaed846ad8525f88fb94bf337
Source dataset: uspto-grants-2014_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08759535B2

Reaction notes

Loading…