HCID 2823414, compound → Methyl 3-Amino-4-(Isopropylamino)Benzoate

HRID 410891Notes

Reaction equation

HRID 410891 reaction equation
[CH3:1][O:2][C:3](=[O:17])[C:4]1[CH:9]=[CH:8][C:7]([NH:10][CH:11]([CH3:13])[CH3:12])=[C:6]([N+:14]([O-])=O)[CH:5]=1>CO.CCOC(C)=O.[Pd]>[CH3:1][O:2][C:3](=[O:17])[C:4]1[CH:9]=[CH:8][C:7]([NH:10][CH:11]([CH3:13])[CH3:12])=[C:6]([NH2:14])[CH:5]=1

Participants

4

Reactant 1

HCID 2823414HCID 2823414, compound

Product 1

HCID 2736795Methyl 3-Amino-4-(Isopropylamino)BenzoateYield 89%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 21584119Ethylacetate methanolSolvent

Procedure

3-Amino-4-isopropylamino-benzoic acid methyl ester (700.0 mg) was prepared by following General Procedure B starting from 4-isopropylamino-3-nitro-benzoic acid methyl ester (900.0 mg) and Pd/C (20% by weight, 180.0 mg) in MeOH:EtOAc (1:1, 10.0 mL). The crude product was used in the next step without further purification.

Workup

  1. customThe crude product was used in the next step without further purification

Sources & evidence

ORD record
ord-89419a633a5b401fa745458e45fd0e58
Source dataset
uspto-grants-2014_06
Patent number
US08759535B2

Reaction notes

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