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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 410941Generated: October 27, 2026

1,2-Dichloroethane → 1-Ethyl-2-[6-(pyridin-3-yloxy)-benzothiazol-2-ylamino]-1H-benzoimidazole-5-carboxylic acid methyl ester

https://huagongshe.com/reaction/410941

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1,2-DichloroethaneHCID 11—
Reactant1,1'-ThiocarbonyldiimidazoleHCID 80264—
ReactantMethyl 3-amino-4-(ethylamino)benzoateHCID 12758354—
Reactant6-(Pyridin-3-yloxy)-benzothiazol-2-ylamineHCID 86656876—
SolventDimethylformamideHCID 6228—
Product1-Ethyl-2-[6-(pyridin-3-yloxy)-benzothiazol-2-ylamino]-1H-benzoimidazole-5-carboxylic acid methyl esterHCID 8665687542.3%

Reaction Steps

1-Ethyl-2-[6-(pyridin-3-yloxy)-benzothiazol-2-ylamino]-1H-benzoimidazole-5-carboxylic acid methyl ester (155.0 mg) was prepared by following General Procedure D starting from 3-amino-4-ethylamino-benzoic acid methyl ester (160.0 mg), 6-(pyridin-3-yloxy)-benzothiazol-2-ylamine (200.0 mg), 1,1′-thiocarbonyldiimidazole (200.0 mg), and EDC (200.0 mg) in DMF (2.0 mL).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08759535B2
Source datasetuspto-grants-2014_06
ORD IDord-fb74c3f1676245998084836a4d30d8d3
Source noteuspto-grants-2014_06