4-(Methylamino)-3-nitrobenzonitrile → 3-Amino-4-(methylamino)benzonitrile

HRID 410946Notes

Reaction equation

HRID 410946 reaction equation
[CH3:1][NH:2][C:3]1[CH:10]=[CH:9][C:6]([C:7]#[N:8])=[CH:5][C:4]=1[N+:11]([O-])=O>[Pd]>[NH2:11][C:4]1[CH:5]=[C:6]([CH:9]=[CH:10][C:3]=1[NH:2][CH3:1])[C:7]#[N:8]

Participants

3

Reactant 1

HCID 46007154-(Methylamino)-3-nitrobenzonitrile

Product 1

HCID 27797313-Amino-4-(methylamino)benzonitrileYield 0.1%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

3-Amino-4-methylamino-benzonitrile (1.23 mg) was prepared by following General Procedure B starting from 4-methylamino-3-nitro-benzonitrile (1.33 g) and Pd/C (10% by weight, 133 mg). The crude product was used in the next step without further purification.

Workup

  1. customThe crude product was used in the next step without further purification

Sources & evidence

ORD record
ord-1f1675ebf3384b15baa6f0c22ffe8181
Source dataset
uspto-grants-2014_06
Patent number
US08759535B2

Reaction notes

Loading…