1-[4-(Methylamino)-3-nitrophenyl]ethan-1-one → 1-[3-Amino-4-(methylamino)phenyl]ethan-1-one

HRID 410953Notes

Reaction equation

HRID 410953 reaction equation
[CH3:1][NH:2][C:3]1[CH:8]=[CH:7][C:6]([C:9](=[O:11])[CH3:10])=[CH:5][C:4]=1[N+:12]([O-])=O>[Pd]>[NH2:12][C:4]1[CH:5]=[C:6]([C:9](=[O:11])[CH3:10])[CH:7]=[CH:8][C:3]=1[NH:2][CH3:1]

Participants

3

Reactant 1

HCID 131756261-[4-(Methylamino)-3-nitrophenyl]ethan-1-one

Product 1

HCID 27797691-[3-Amino-4-(methylamino)phenyl]ethan-1-oneYield 80.5%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

1-(3-Amino-4-methylamino-phenyl)-ethanone (66 mg) was prepared by following General Procedure B starting from 1-(4-methylamino-3-nitro-phenyl)-ethanone (97 mg) and Pd/C (10% by weight, 10 mg). The crude product was used in the next step without further purification.

Workup

  1. customThe crude product was used in the next step without further purification

Sources & evidence

ORD record
ord-87f8acde2523403796d8989aa2db0b03
Source dataset
uspto-grants-2014_06
Patent number
US08759535B2

Reaction notes

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