化工社化工社 化学情報印刷レポート · 研究参考用
N-(2-Chloroethyl)dibenzylamine → N,N-Dibenzyl-N'-(2-fluoro-ethyl)ethane-1,2-diamine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-(2-Chloroethyl)dibenzylamine | HCID 5820 | — |
| 反応物 | Ethanamine, 2-fluoro-, hydrochloride | HCID 9995 | — |
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 触媒 | Tetrabutylammonium Bromide | HCID 74236 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | N,N-Dibenzyl-N'-(2-fluoro-ethyl)ethane-1,2-diamine | HCID 86656909 | 27.9% |
反応手順
N,N-Dibenzyl-N′-(2-fluoro-ethyl)ethane-1,2-diamine (160 mg) was prepared by following General Procedure S starting from dibenzyl-(2-chloro-ethyl)-amine (520 mg), 2-fluoro-ethylamine hydrochloride (250 mg), DIEA (900 uL) and tetrabutylammonium bromide (60 mg) in DMF (2 mL).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08759535B2 |
| 出典データセット | uspto-grants-2014_06 |
| ORD ID | ord-5a18b1a3eb32402cb0d51adcaa7437dd |
| 出典メモ | uspto-grants-2014_06 |